The IMAGEN project, “Reinforcement-related behaviour in normal brain function and psychopathology” has recruited n=2090 participants from four European countries, UK, Germany, France and Ireland. Baseline assessment was at age 14 years, with follow-up assessments at 16 years, 19 years, and 23 years (ongoing). IMAGEN measures include functional neuroimaging, including resting state and tasks assessing reward processing (Monetary Incentive Delay, MID; impulsiveness (Stop Signal Reaction Time, SSRT; socialemotional processing (Emotional Faces Task, EFT; and resting state. –genomics characterisation comprise genome-wide genomic (including exome sequencing), gene expression and epigenetic methylation data. Neuropsychological measures include IQ and executive function using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Clinical phenotypes were indexed using the Development and Wellbeing Assessment (DAWBA) and Strengths and Difficulties Questionnaire (SDQ). There is an extensive characterisation of behavioural measures related to externalising behaviour and substance use.
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